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The study of metallocene anticancer therapeutics-cells interaction
Bilavčíková, Kristýna ; Mravcová, Ludmila (referee) ; Vašinová Galiová, Michaela (advisor)
There were almost 600 thousand patients in Czech Republic until 2017 and the number keeps rising. Chemotherapeutics used today have lots of undesirable side effects, so scientists around the world are trying hard to find more specific and less cytotoxic drugs. In this bachelor’s thesis, potential drugs based on metallocene with a central atom of Ru, Hf or Zr were studied, always in three different drugs for each element. The permeability and distribution of these drugs into lung cancer cell lines were investigated. These drugs were detected by analysis of solutions and laser ablation with an ICP mass spectrometer. Based on the experiment, the greatest potential was found for the ruthenium-based drug 133, which had the highest permeability and was able to get into the cells in the highest volume.
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Nuclear Fuel in Operational Conditions
Konopová, Tamara ; Novotný, Filip (referee) ; Katovský, Karel (advisor)
This thesis deals with the issue of nuclear fuel. Firstly, the problem of nuclear fuel in the implementation for certain reactors is presented. Production of nuclear fuel is introduced, which includes the performance of companies engaged in the production of this fuel. Secondly, the phenomena in the fuel burnup are discussed. Lastly, the burnable absorbers are mentioned and the analysis of burnable absorbers is carried out.
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The study of metallocene anticancer therapeutics-cells interaction
Bilavčíková, Kristýna ; Mravcová, Ludmila (referee) ; Vašinová Galiová, Michaela (advisor)
There were almost 600 thousand patients in Czech Republic until 2017 and the number keeps rising. Chemotherapeutics used today have lots of undesirable side effects, so scientists around the world are trying hard to find more specific and less cytotoxic drugs. In this bachelor’s thesis, potential drugs based on metallocene with a central atom of Ru, Hf or Zr were studied, always in three different drugs for each element. The permeability and distribution of these drugs into lung cancer cell lines were investigated. These drugs were detected by analysis of solutions and laser ablation with an ICP mass spectrometer. Based on the experiment, the greatest potential was found for the ruthenium-based drug 133, which had the highest permeability and was able to get into the cells in the highest volume.
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|
|
Nuclear Fuel in Operational Conditions
Konopová, Tamara ; Novotný, Filip (referee) ; Katovský, Karel (advisor)
This thesis deals with the issue of nuclear fuel. Firstly, the problem of nuclear fuel in the implementation for certain reactors is presented. Production of nuclear fuel is introduced, which includes the performance of companies engaged in the production of this fuel. Secondly, the phenomena in the fuel burnup are discussed. Lastly, the burnable absorbers are mentioned and the analysis of burnable absorbers is carried out.
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